pentobarbital will decrease the extent or outcome of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to some lower in fentanyl plasma concentrations, lack of efficacy or, quite possibly, growth of a withdrawal syndrome within a client who's got formulated physical dependence to fentanyl.

pentobarbital will reduce the extent or effect of buprenorphine, long-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Patients who transfer to buprenorphine extensive-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers ought to be monitored to ensure buprenorphine plasma levels are adequate.

pentobarbital will decrease the extent or effect of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.

pentobarbital will reduce the extent or influence of bazedoxifene/conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will decrease the extent or influence of clozapine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

pentobarbital will reduce the extent or outcome of alosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.

pentobarbital decreases consequences of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of CYP3A4 inducers may well minimize sufentanil levels and efficacy, potentially precipitating withdrawal syndrome in clients who've created physical dependence to sufentanil. Discontinuation of concomitantly utilized CYP3A4 inducers may well maximize sufentanil plasma concentration.

pentobarbital will reduce the level or influence of fostemsavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

Remark: Barbiturates may perhaps increase adverse effects, including respiratory melancholy, made by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.

pentobarbital will minimize the extent or effect of losartan by impacting hepatic enzyme CYP2C9/ten metabolism. Slight/Importance Unfamiliar.

pentobarbital will lower the extent or impact of dasatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.

pentobarbital will reduce the extent or outcome of parecoxib by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Keep read more track of.

pentobarbital will minimize the extent or impact of voriconazole by affecting hepatic enzyme CYP2C9/ten metabolism. Small/Importance Mysterious.